Article
The absence of Ku but not defects in classical non-homologous end-joining is required to trigger PARP1-dependent end-joining.
DNA repair - 1 Dec 2013
Mansour Wael Y, Borgmann K, Petersen C, Dikomey Ekkehard, Dahm-Daphi Jochen
Abstract excerpt
Classical-non-homologous end-joining (C-NHEJ) is considered the main pathway for repairing DNA double strand breaks (DSB) in mammalian cells. When C-NHEJ is defective, cells may switch DSB repair to an alternative-end-joining, which depends on PARP1 and is more erroneous. This PARP1-EJ is suggested to be active especially in tumor cells contributing to their genomic instability. Here, we define conditions under...
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