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Article

Microevolution of the direct repeat region of Mycobacterium tuberculosis: implications for interpretation of spoligotyping data.

Journal of clinical microbiology - 1 Dec 2002

Warren R M, Streicher E M, Sampson S L, van der Spuy G D, Richardson M, Nguyen D, Behr M A, Victor T C, van Helden P D

Abstract excerpt

The direct repeat (DR) region has been determined to be an important chromosomal domain for studying the evolution of Mycobacterium tuberculosis. Despite this, very little is known about microevolutionary events associated with clonal expansion and how such events influence the interpretation of both restriction fragment length polymorphism (RFLP) and spoligotype data. This study examined the structure of the DR...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12454136
DOI: 10.1128/JCM.40.12.4457-4465.2002
PMCID: PMC154636

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Source receipt: pubmed, retrieved 7 Sept 2026.

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