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Article

Discovery of a novel Mycobacterium tuberculosis lineage that is a major cause of tuberculosis in Rio de Janeiro, Brazil.

Journal of clinical microbiology - 1 Dec 2007

Lazzarini Luiz Claudio Oliveira, Huard Richard C, Boechat Neio L, Gomes Harrison M, Oelemann Maranibia C, Kurepina Natalia, Shashkina Elena, Mello Fernanda C Q, Gibson Andrea L, Virginio Milena J, Marsico Ana Grazia, Butler W Ray, Kreiswirth Barry N, Suffys Philip N, Lapa E Silva Jose Roberto, Ho John L

Abstract excerpt

The current study evaluated Mycobacterium tuberculosis isolates from Rio de Janeiro, Brazil, for genomic deletions. One locus in our panel of PCR targets failed to amplify in approximately 30% of strains. A single novel long sequence polymorphism (>26.3 kb) was characterized and designated RD(Rio). Homologous recombination between two similar protein-coding genes is proposed as the mechanism for deleting or...

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Identifiers

PMID: 17898156
DOI: 10.1128/JCM.01394-07
PMCID: PMC2168543

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