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Article

Casein kinase II phosphorylates the fragile X mental retardation protein and modulates its biological properties.

Molecular and cellular biology - 1 Dec 2002

Siomi Mikiko C, Higashijima Kyoko, Ishizuka Akira, Siomi Haruhiko

Abstract excerpt

Fragile X syndrome is caused by loss of FMR1 protein expression. FMR1 binds RNA and associates with polysomes in the cytoplasm; thus, it has been proposed to function as a regulator of gene expression at the posttranscriptional level. Posttranslational modification of FMR1 had previously been suggested to regulate its activity, but no experimental support for this model has been reported to date. Here we report...

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Identifiers

PMID: 12446764
DOI: 10.1128/MCB.22.24.8438-8447.2002
PMCID: PMC139871

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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