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Article

Vancomycin tolerance induced by erythromycin but not by loss of vncRS, vex3, or pep27 function in Streptococcus pneumoniae.

Journal of bacteriology - 1 Dec 2002

Robertson Gregory T, Zhao Jingyong, Desai Bhushan V, Coleman William H, Nicas Thalia I, Gilmour Raymond, Grinius Leo, Morrison Donald A, Winkler Malcolm E

Abstract excerpt

Vancomycin-tolerant Streptococcus pneumoniae is a growing problem among drug-resistant human pathogens. Some vancomycin-tolerant pneumococci have been reported to carry mutations in loci encoding a two-component regulatory system designated VncRS or in a proximal ABC transporter, Vex. A model was advanced proposing that the tolerance phenotype resulted from the inability of a vncS mutant to respond to the...

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Identifiers

PMID: 12446649
DOI: 10.1128/JB.184.24.6987-7000.2002
PMCID: PMC135460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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