Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defective cell wall synthesis in Streptococcus pneumoniae R6 depleted for the essential PcsB putative murein hydrolase or the VicR (YycF) response regulator.

Molecular microbiology - 1 Aug 2004

Ng Wai-Leung, Kazmierczak Krystyna M, Winkler Malcolm E

Abstract excerpt

PcsB is a protein of unknown function(s) that influences the cell morphology of several pathogenic species of streptococcus. PcsB contains a CHAP (cysteine, histidine-dependent amidohydrolase/peptidase) domain found in bacterial murein hydrolases; however, direct links between steps in cell wall biosynthesis and PcsB function(s) have not been demonstrated. We show here that pcsB is essential in the human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle Proteins

Share to Cell Wall

Share to Gene Expression Regulation, Bacterial

Share to Genes, Essential

Share to N-Acetylmuramoyl-L-alanine Amidase

Share to Streptococcus pneumoniae

Source

Identifiers

PMID: 15306019
DOI: 10.1111/j.1365-2958.2004.04196.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defective cell wall synthesis in Streptococcus pneumoniae R6 depleted for the essential PcsB putative murein hydrolase or the VicR (YycF) response regulator.PMID 15306019Read ↗

Characterization of mutants deficient in the L,D-carboxypeptidase (DacB) and WalRK (VicRK) regulon, involved in peptidoglycan maturation of Streptococcus pneumoniae serotype 2 strain D39.Semantic proximity Read ↗

High‐throughput CRISPRi phenotyping identifies new essential genes in Streptococcus pneumoniaeSemantic proximity Read ↗

High-throughput CRISPRi phenotyping in <i>Streptococcus pneumoniae</i> identifies new essential genes involved in cell wall synthesis and competence developmentSemantic proximity Read ↗

Essential PcsB putative peptidoglycan hydrolase interacts with the essential FtsX <sub> <i>Spn</i> </sub> cell division protein in <i>Streptococcus pneumoniae</i> D39Semantic proximity Read ↗

Requirement of essential Pbp2x and GpsB for septal ring closure in Streptococcus pneumoniae D39.Semantic proximity Read ↗

Constitutive expression of PcsB suppresses the requirement for the essential VicR (YycF) response regulator in <i>Streptococcus pneumoniae</i> R6<sup>§</sup>Semantic proximity Read ↗

The puzzle of zmpB and extensive chain formation, autolysis defect and non-translocation of choline-binding proteins in Streptococcus pneumoniae.Semantic proximity Read ↗

Effects of low PBP2b levels on cell morphology and peptidoglycan composition in Streptococcus pneumoniae R6.Semantic proximity Read ↗

Roles of the Essential Protein FtsA in Cell Growth and Division in Streptococcus pneumoniaeSemantic proximity Read ↗

Competence remodels the pneumococcal cell wall exposing key surface virulence factors that mediate increased host adherenceSemantic proximity Read ↗

A CozE Homolog Contributes to Cell Size Homeostasis of Streptococcus pneumoniae.Semantic proximity Read ↗

Overexpression of the fratricide immunity protein ComM leads to growth inhibition and morphological abnormalities in Streptococcus pneumoniaeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.