Article
Tolerance to vancomycin in pneumococci: detection with a molecular marker and assessment of clinical impact.
The Journal of infectious diseases - 15 Oct 2004
Rodriguez Carina A, Atkinson Robyn, Bitar Wally, Whitney Cynthia G, Edwards Kathryn M, Mitchell Lauren, Li Juan, Sublett Jack, Li Chin-Shang, Liu Tiebin, Chesney P Joan, Tuomanen Elaine I
Abstract excerpt
BACKGROUND: Vancomycin is often added to therapy for meningitis caused by Streptococcus pneumoniae. Tolerant bacteria without classic resistance that escape killing by multiple antibiotics have been reported sporadically. We determined the prevalence of tolerance to vancomycin in pneumococci and its effect on the outcome of meningitis. METHODS: Archival samples of 215 nasopharyngeal (NP) and 113 meningitis...
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