Capsular Expression in<i>Streptococcus pneumoniae</i>Negatively Affects Spontaneous and Antibiotic‐Induced Lysis and Contributes to Antibiotic Tolerance

Abstract excerpt

Penicillin and vancomycin induce a lytic response in Streptococcus pneumoniae that requires the N-acetylmuramyl-l-alanine amidase LytA. We show that clinical isolates of pneumococci of capsular serotypes 1, 4, 6B, and 23F were generally less lytic to penicillin than pneumococci of serotypes 14 and 3. In addition, most 9V isolates were less lytic to vancomycin, compared with isolates of other serotypes....

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