Article
Regulation of postischemic liver injury following different durations of ischemia.
American journal of physiology. Gastrointestinal and liver physiology - 1 Mar 2003
Hines Ian N, Hoffman Jason M, Scheerens Heleen, Day Brian J, Harada Hirohisa, Pavlick Kevin P, Bharwani Sulaiman, Wolf Robert, Gao Bifeng, Flores Sonia, McCord Joe M, Grisham Matthew B
Abstract excerpt
The objective of this study was to define the relationship among Kupffer cells, O(2)(-) production, and TNF-alpha expression in the pathophysiology of postischemic liver injury following short and long periods of ischemia. Using different forms of superoxide dismutase with varying circulating half-lives, a monoclonal antibody directed against mouse TNF-alpha, and NADPH oxidase-deficient mice, we found that 45 or...
Topics
- Alanine Transaminase
- Animals
- Cytokines
- Hepatectomy
- Humans
- Ischemia
- Kupffer Cells
- Liver
- Liver Circulation
- Mice
- Mice, Inbred C57BL
- Mutation
- NADPH Oxidases