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Article

Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferase.

Neuron - 14 Nov 2002

Misgeld Thomas, Burgess Robert W, Lewis Renate M, Cunningham Jeanette M, Lichtman Jeff W, Sanes Joshua R

Abstract excerpt

Activity-dependent and -independent signals collaborate to regulate synaptogenesis, but their relative contributions are unclear. Here, we describe the formation of neuromuscular synapses at which neurotransmission is completely and specifically blocked by mutation of the neurotransmitter-synthesizing enzyme choline acetyltransferase. Nerve terminals differentiate extensively in the absence of neurotransmitter,...

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Identifiers

PMID: 12441053
DOI: 10.1016/s0896-6273(02)01020-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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