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Article

Novel mouse model reveals distinct activity-dependent and -independent contributions to synapse development.

PloS one - 31 Jan 2011

Pacifici Pier Giorgio, Peter Christoph, Yampolsky Pessah, Koenen Michael, McArdle Joseph J, Witzemann Veit

Abstract excerpt

The balanced action of both pre- and postsynaptic organizers regulates the formation of neuromuscular junctions (NMJ). The precise mechanisms that control the regional specialization of acetylcholine receptor (AChR) aggregation, guide ingrowing axons and contribute to correct synaptic patterning are unknown. Synaptic activity is of central importance and to understand synaptogenesis, it is necessary to...

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Source

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Identifiers

PMID: 21305030
DOI: 10.1371/journal.pone.0016469
PMCID: PMC3031568

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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