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Article

Role of canonical Wnt signaling in endometrial carcinogenesis

8 Dec 2011

Abstract excerpt

While the role of Wnt signaling is well established in colorectal carcinogenesis, its function in gynecologic cancers has not been elucidated. Here, we describe the current state of knowledge of canonical Wnt signaling in endometrial cancer (EC), and its implications for future therapeutic targets. Deregulation of the Wnt/β-catenin signaling pathway in EC occurs by inactivating β-catenin mutations in...

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PMID: 22149432
DOI: 10.1586/era.11.194

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