Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Peptidoglycan N-acetylglucosamine deacetylase, a putative virulence factor in Streptococcus pneumoniae.

Infection and immunity - 1 Dec 2002

Vollmer Waldemar, Tomasz Alexander

Abstract excerpt

Many glucosamine residues of the pneumococcal peptidoglycan (PG) are not acetylated, which makes the PG resistant to lysozyme. A capsular type III mutant with an inactivated pgdA gene (encoding the peptidoglycan N-acetylglucosamine deacetylase A) became hypersensitive to exogenous lysozyme and showed reduced virulence in the intraperitoneal mouse model.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amidohydrolases
Share to Bacterial Proteins
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muramidase

Share to Pneumococcal Infections

Share to Streptococcus pneumoniae

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 12438406
DOI: 10.1128/IAI.70.12.7176-7178.2002
PMCID: PMC133073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Peptidoglycan N-acetylglucosamine deacetylase, a putative virulence factor in Streptococcus pneumoniae.PMID 12438406Read ↗

The pgdA gene encodes for a peptidoglycan N-acetylglucosamine deacetylase in Streptococcus pneumoniae.Semantic proximity Read ↗

Significant contribution of the pgdA gene to the virulence of Streptococcus suis.Semantic proximity Read ↗

Impact of cell wall peptidoglycan O-acetylation on the pathogenesis of Staphylococcus aureus in septic arthritis.Semantic proximity Read ↗

The lysozyme-induced peptidoglycan N-acetylglucosamine deacetylase PgdA (EF1843) is required for Enterococcus faecalis virulence.Semantic proximity Read ↗

Characterization of SfPgdA, a Shigella flexneri peptidoglycan deacetylase required for bacterial persistence within polymorphonuclear neutrophils.Semantic proximity Read ↗

The Presence of Peptidoglycan O -Acetyltransferase in Various Staphylococcal Species Correlates with Lysozyme Resistance and PathogenicitySemantic proximity Read ↗

PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharidesSemantic proximity Read ↗

PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharidesSemantic proximity Read ↗

A bacterial cell wall repair and modification system to resist host antibacterial factorsSemantic proximity Read ↗

Resistance to mucosal lysozyme compensates for the fitness deficit of peptidoglycan modifications by Streptococcus pneumoniae.Semantic proximity Read ↗

Contribution of N ε -lysine Acetylation towards Regulation of Bacterial PathogenesisSemantic proximity Read ↗

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.