PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides

doi:10.1038/s41467-022-28257-0

Article

PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides

1 Feb 2022

Abstract excerpt

The cell wall of the human bacterial pathogen Group A Streptococcus (GAS) consists of peptidoglycan decorated with the Lancefield group A carbohydrate (GAC). GAC is a promising target for the development of GAS vaccines. In this study, employing chemical, compositional, and NMR methods, we show that GAC is attached to peptidoglycan via glucosamine 1-phosphate. This structural feature makes the GAC-peptidoglycan...

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