Article
Phosphatidylserine induces apoptosis in CHO cells without mitochondrial dysfunction in a manner dependent on caspases other than caspases-1, -3, -8 and -9.
FEBS letters - 24 Aug 2001
Miyato Y, Ibuki Y, Ohyama H, Yamada T, Goto R
Abstract excerpt
Treatment of Chinese hamster ovary K1 cells with phosphatidylserine (PS) caused typical apoptosis with distinct morphological and biochemical features in a dose- and time-dependent manner. However, unlike camptothecin-induced apoptosis, changes in mitochondrial transmembrane potential were not observed. In addition, cytochrome c release did not occur in PS-induced apoptosis. A pan caspase inhibitor, Z-VAD,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
