Antibody‐based screening for hereditary nonpolyposis colorectal carcinoma compared with microsatellite analysis and sequencing

Abstract excerpt

BACKGROUND: Germline mutations in the DNA mismatch repair genes, MSH2, MLH1, and others are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Due to the high costs of sequencing, cheaper screening methods are needed to identify HNPCC cases. Ideally, these methods should have a high sensitivity and identify all mutated cases without too many false-positive cases. METHODS: Sequencing was compared...

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