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Increased Calcium Influx through L-Type Calcium Channels in Hippocampal Neurons with Exogenous Expression of Presenilin-1 ΔE9 Mutant.

Bulletin of experimental biology and medicine - 1 Apr 2022

Skobeleva K V, Ryazantseva М A, Kaznacheyeva Е V

Abstract excerpt

Mutations in the PSEN1 gene encoding presenilin-1 (PS1) protein are the most common cause of familial Alzheimer's disease. One of these, deletion of exon 9, results in the production of shortened PS1 protein (PS1ΔE9). Neuronal hyperexcitability and hyperactivation of L-type calcium channels were observed in cellular and animal models of familial Alzheimer's disease. However, the effect of PS1ΔE9 on L-type calcium...

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PMID: 35503587
DOI: 10.1007/s10517-022-05478-3

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