Article
Mutation of the Drosophila melanogaster serotonin transporter dSERT impacts sleep, courtship, and feeding behaviors.
PLoS genetics - 1 Nov 2022
Knapp Elizabeth M, Kaiser Andrea, Arnold Rebecca C, Sampson Maureen M, Ruppert Manuela, Xu Li, Anderson Matthew I, Bonanno Shivan L, Scholz Henrike, Donlea Jeffrey M, Krantz David E
Abstract excerpt
The Serotonin Transporter (SERT) regulates extracellular serotonin levels and is the target of most current drugs used to treat depression. The mechanisms by which inhibition of SERT activity influences behavior are poorly understood. To address this question in the model organism Drosophila melanogaster, we developed new loss of function mutations in Drosophila SERT (dSERT). Previous studies in both flies and...
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