Article
The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.
Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2002
Jonker Johan W, Buitelaar Marije, Wagenaar Els, Van Der Valk Martin A, Scheffer George L, Scheper Rik J, Plosch Torsten, Kuipers Folkert, Elferink Ronald P J Oude, Rosing Hilde, Beijnen Jos H, Schinkel Alfred H
Abstract excerpt
The breast cancer resistance protein (BCRPABCG2) is a member of the ATP-binding cassette family of drug transporters and confers resistance to various anticancer drugs. We show here that mice lacking Bcrp1Abcg2 become extremely sensitive to the dietary chlorophyll-breakdown product pheophorbide a, resulting in severe, sometimes lethal phototoxic lesions on light-exposed skin. Pheophorbide a occurs in various...
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