Article
Outcome in prostate cancer: association with endothelial nitric oxide synthase Glu-Asp298 polymorphism at exon 7.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2002
Medeiros Rui M, Morais Antonio, Vasconcelos André, Costa Sandra, Pinto Daniela, Oliveira Jorge, Ferreira Paula, Lopes Carlos
Abstract excerpt
PURPOSE: The endothelial cell-specific form of nitric oxide synthases (ecNOS) was mapped at 7q35-q36 and plays an important role in vascular development and tumor growth in human prostate cancer. Bone metastasis, clinical T-stage, tumor grade, and serum prostate-specific antigen (PSA) have been shown to have prognostic importance in the outcome of prostate cancer. The purpose of this study was to evaluate ecNOS...
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