Article
Endothelial nitric oxide synthase gene polymorphisms and genetic susceptibility to prostate cancer.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) - 1 Aug 2002
Medeiros R, Morais A, Vasconcelos A, Costa S, Pinto D, Oliveira J, Lopes C
Abstract excerpt
The endothelial cell-specific form of nitric oxide synthases (ecNOS) is localized at 7q35-q36 and is involved in vascular development and tumour growth in human prostate cancer. We have conducted a case-control study to investigate the prevalence of two polymorphisms at intron 4 (ecNOS4a/b) and exon 7 (Glu-Asp298) of ecNOS gene in 125 prostate cancer (PCa) patients and in 153 controls. We observed that the...
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