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Article

Endothelial nitric oxide synthase gene polymorphisms and the shedding of circulating tumour cells in the blood of prostate cancer patients.

Cancer letters - 10 Jan 2003

Medeiros Rui, Morais Antonio, Vasconcelos André, Costa Sandra, Carrilho Susana, Oliveira Jorge, Lopes Carlos

Abstract excerpt

The involvement of endothelial nitric oxide synthase (ecNOS) gene polymorphisms (ecNOS4a/b and Glu-Asp298) on the shedding of tumor cells in the blood of 61 patients with prostate cancer (PCa), was analyzed. Hematogenous micrometastasis with blood circulating tumor cells (CTCs) may be an early event in the natural history of PCa metastization. CTCs can be detected by the presence of messenger RNA prostate...

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Identifiers

PMID: 12445681
DOI: 10.1016/s0304-3835(02)00118-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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