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Article

Activation of calpain in cultured neurons overexpressing Alzheimer amyloid precursor protein.

Brain research. Molecular brain research - 15 Nov 2002

Kuwako Ken-ichiro, Nishimura Isao, Uetsuki Taichi, Saido Takaomi C, Yoshikawa Kazuaki

Abstract excerpt

We have previously reported that overexpression of wild-type amyloid precursor protein (APP) in postmitotic neurons induces cleavage-dependent activation of caspase-3 both in vivo and in vitro. In this study, we investigated the mechanism underlying APP-induced caspase-3 activation using adenovirus-mediated gene transfer into postmitotic neurons derived from human embryonal carcinoma NT2 cells. Overexpression of...

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Source

Identifiers

PMID: 12425945
DOI: 10.1016/s0169-328x(02)00489-8

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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