Article
High level calcineurin activity predisposes neuronal cells to apoptosis.
The Journal of biological chemistry - 26 Nov 1999
Asai A, Qiu J h, Narita Y, Chi S, Saito N, Shinoura N, Hamada H, Kuchino Y, Kirino T
Abstract excerpt
Calcineurin is a Ca(2+)/calmodulin-dependent protein phosphatase that is abundantly expressed in several specific areas of the brain, which are exceptionally vulnerable to stroke, epilepsy, and neurodegenerative diseases. In this study, we assessed the effects of high level activity of calcineurin on neuronal cells. Virus-mediated high level constitutive activity of calcineurin rendered neuronal cells susceptible...
Topics
- Adenoviruses, Human
- Animals
- Apoptosis
- Calcimycin
- Calcineurin
- Calcium
- Caspase 3
- Caspases
- Cell Line
- Cerebral Cortex
- Cyclosporine
- Cysteine Proteinase Inhibitors
- Enzyme Activation
- Gene Expression