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Article

Characterization of a nuclear-factor-kappa B (NFkappaB) genetic marker in type 1 diabetes (T1DM) families.

Genes and immunity - 1 Nov 2002

Gylvin T, Bergholdt R, Nerup J, Pociot F

Abstract excerpt

Cytokine-induced beta-cell death is an important factor in the pathogenesis of type 1 diabetes mellitus (T1DM). The transcription factor NFkappaB plays an important role in cytokine-induced gene activation. Hence, NFKB1 is a possible candidate gene for T1DM disposition. A polymorphic (CA) dinucleotide repeat microsatellite has been identified near the NFKB1 gene. In a recent case-control study certain alleles of...

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Identifiers

PMID: 12424626
DOI: 10.1038/sj.gene.6363916

Genes

NFKB1

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Characterization of a nuclear-factor-kappa B (NFkappaB) genetic marker in type 1 diabetes (T1DM) families.PMID 12424626Read ↗

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