Article
Haploinsufficiency of the NF1 gene is associated with protection against diabetes.
Journal of medical genetics - 1 Jun 2021
Kallionpää Roope A, Peltonen Sirkku, Leppävirta Jussi, Pöyhönen Minna, Auranen Kari, Järveläinen Hannu, Peltonen Juha
Abstract excerpt
BACKGROUND: The hereditary predisposition to diabetes is only partially explained by genes identified so far. Neurofibromatosis type 1 (NF1) is a rare monogenic dominant syndrome caused by aberrations of the NF1 gene. Here, we used a cohort of 1410 patients with NF1 to study the association of the NF1 gene with type 1 (T1D) and type 2 diabetes (T2D). METHODS: A total of 1410 patients were confirmed to fulfil the...
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