Article
Mutations in spalt cause a severe but reversible neurodegenerative phenotype in the embryonic central nervous system of Drosophila melanogaster.
Development (Cambridge, England) - 1 Dec 2002
Cantera Rafael, Lüer Karin, Rusten Tor Erik, Barrio Rosa, Kafatos Fotis C, Technau Gerhard M
Abstract excerpt
The gene spalt is expressed in the embryonic central nervous system of Drosophila melanogaster but its function in this tissue is still unknown. To investigate this question, we used a combination of techniques to analyse spalt mutant embryos. Electron microscopy showed that in the absence of spalt, the central nervous system cells are separated by enlarged extracellular spaces populated by membranous material at...
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