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Article

Proteomic changes associated with inactivation of the Candida glabrata ACE2 virulence-moderating gene.

Proteomics - 1 May 2005

Stead David, Findon Helen, Yin Zhikang, Walker Janet, Selway Laura, Cash Philip, Dujon Bernard A, Hennequin Christophe, Brown Alistair J P, Haynes Ken

Abstract excerpt

Inactivation of the gene encoding the transcriptional activator Ace2 in the fungal pathogen Candida glabrata results in an almost 200-fold increase in virulence characterised by acute mortality and a massive over-stimulation of the pro-inflammatory arm of the innate immune system. In this study w...

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Source

Identifiers

PMID: 15825152
DOI: 10.1002/pmic.200401064

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15825152-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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