Article
Association studies between microsatellite markers within the gene encoding human 11beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism.
The Journal of clinical endocrinology and metabolism - 1 Nov 2002
Draper N, Echwald S M, Lavery G G, Walker E A, Fraser R, Davies E, Sørensen T I A, Astrup A, Adamski J, Hewison M, Connell J M, Pedersen O, Stewart P M
Abstract excerpt
Two isozymes of 11beta-hydroxysteroid dehydrogenase (11beta-HSD) interconvert active cortisol (F) and inactive cortisone (E). 11beta-HSD1 is an oxo-reductase (E to F) expressed in several glucocorticoid target tissues, including liver and adipose tissue, where it facilitates glucocorticoid-induced gluconeogenesis and adipocyte differentiation, respectively. We have isolated a full-length HSD11B1 genomic clone;...
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