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Article

Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans.

Journal of cell science - 15 Mar 2007

Tóth Márton L, Simon Péter, Kovács Attila L, Vellai Tibor

Abstract excerpt

Necrotic cell death is a common feature in numerous human neurodegenerative disorders. In the nematode Caenorhabditis elegans, gain-of-function mutations in genes that encode specific ion channel subunits such as the degenerins DEG-1 and MEC-4, and the acetylcholine receptor subunit DEG-3 lead to necrotic-like degeneration of a subset of neurons. Neuronal demise caused by ion channel hyperactivity is accompanied...

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PMID: 17327275
DOI: 10.1242/jcs.03401

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Source receipt: pubmed, retrieved 7 Sept 2026.

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