Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans.

doi:10.1242/jcs.03401

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Article

Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans.

Journal of cell science - 15 Mar 2007

Tóth Márton L, Simon Péter, Kovács Attila L, Vellai Tibor

Abstract excerpt

Necrotic cell death is a common feature in numerous human neurodegenerative disorders. In the nematode Caenorhabditis elegans, gain-of-function mutations in genes that encode specific ion channel subunits such as the degenerins DEG-1 and MEC-4, and the acetylcholine receptor subunit DEG-3 lead to necrotic-like degeneration of a subset of neurons. Neuronal demise caused by ion channel hyperactivity is accompanied...

Topics

Adrenergic Agents
Animals
Autophagy
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Ion Channels
Membrane Proteins
Mutation
Necrosis
Nerve Degeneration
Neurons
Oxidopamine
Phosphotransferases (Alcohol Group Acceptor)
Protein Serine-Threonine Kinases
Signal Transduction
Vesicular Transport Proteins

Source

Open in PubMed

Identifiers

PMID: 17327275
DOI: 10.1242/jcs.03401

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