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The serine protease homolog CLIPA14 modulates the intensity of the immune response in the mosquito Anopheles gambiae

20 Sept 2017

Abstract excerpt

Clip domain serine protease homologs (SPHs) are positive and negative regulators of Anopheles gambiae immune responses mediated by the complement-like protein TEP1 against Plasmodium malaria parasites and other microbial infections. We have previously reported that the SPH CLIPA2 is a negative regulator of the TEP1-mediated response by showing that CLIPA2 knockdown (kd) enhances mosquito resistance to infections...

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PMID: 28928218
DOI: 10.1074/jbc.m117.797787

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