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Article

Functions of Manduca sexta hemolymph proteinases HP6 and HP8 in two innate immune pathways.

The Journal of biological chemistry - 17 Jul 2009

An Chunju, Ishibashi Jun, Ragan Emily J, Jiang Haobo, Kanost Michael R

Abstract excerpt

Serine proteinases in insect plasma have been implicated in two types of immune responses; that is, activation of prophenoloxidase (proPO) and activation of cytokine-like proteins. We have identified more than 20 serine proteinases in hemolymph of the tobacco hornworm, Manduca sexta, but functions are known for only a few of them. We report here functions of two additional M. sexta proteinases, hemolymph...

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Identifiers

PMID: 19487692
DOI: 10.1074/jbc.M109.007112
PMCID: PMC2740596

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