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Article

Effect of spermine conjugation on the cytotoxicity and cellular transport of acridine.

Journal of medicinal chemistry - 7 Nov 2002

Delcros Jean-Guy, Tomasi Sophie, Carrington Simon, Martin Bénédicte, Renault Jacques, Blagbrough Ian S, Uriac Philippe

Abstract excerpt

Polyamines are believed to be potent vectors for the selective delivery of chemotherapeutic agents into cancer cells. In this paper, we report the effect of spermine conjugation on the cytotoxic and transport properties of acridine. Six derivatives, composed of a spermine chain attached at its N(1) position to an acridine via an aliphatic chain, were synthesized. The aliphatic linker, comprised of 3-5 methylene...

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PMID: 12408721
DOI: 10.1021/jm020843w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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