Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Macrophages of genetically characterized familial hypercholesterolaemia patients show up-regulation of LDL-receptor-related proteins.

Journal of cellular and molecular medicine - 1 Mar 2017

Escate Rafael, Padro Teresa, Borrell-Pages Maria, Suades Rosa, Aledo Rosa, Mata Pedro, Badimon Lina

Abstract excerpt

Familial hypercholesterolaemia (FH) is a major risk for premature coronary heart disease due to severe long-life exposure to high LDL levels. Accumulation of LDL in the vascular wall triggers atherosclerosis with activation of the innate immunity system. Here, we have investigated (i) gene expression of LDLR and LRPs in peripheral blood cells (PBLs) and in differentiated macrophages of young FH-patients; and (ii)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Differentiation, Myelomonocytic
Share to CD163 Antigen

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cholesterol, LDL

Share to Hyperlipoproteinemia Type II

Share to LDL-Receptor Related Proteins

Share to Low Density Lipoprotein Receptor-Related Protein-1

Share to Low Density Lipoprotein Receptor-Related Protein-5

Share to Receptors, LDL

Source

Open in PubMed Open full text

Identifiers

PMID: 27680891
DOI: 10.1111/jcmm.12993
PMCID: PMC5323824

Genes

LDLR
LRP1
LRP5
LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Macrophages of genetically characterized familial hypercholesterolaemia patients show up-regulation of LDL-receptor-related proteins.PMID 27680891Read ↗

Circulating CD45+/CD3+ lymphocyte-derived microparticles map lipid-rich atherosclerotic plaques in familial hypercholesterolaemia patients.Semantic proximity Read ↗

Subjects with familial hypercholesterolemia are characterized by an inflammatory phenotype despite long-term intensive cholesterol lowering treatment.Semantic proximity Read ↗

LRP5 associates with specific subsets of macrophages: Molecular and functional effects.Semantic proximity Read ↗

The impact of severe LDL receptor mutations on SREBP-pathway regulation in homozygous familial hypercholesterolemia (FH).Semantic proximity Read ↗

iPSC-Derived Endothelial Cells Reveal LDLR Dysfunction and Dysregulated Gene Expression Profiles in Familial HypercholesterolemiaSemantic proximity Read ↗

Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice.Semantic proximity Read ↗

Identification of an LDLR variant in a Chinese familial hypercholesterolemia and its relation to ROS/NLRP3-Mediated pyroptosis in hepatic cellsSemantic proximity Read ↗

iPSC-Derived Endothelial Cells Reveals LDLR-Dysfunction and Dysregulated Gene Expression Profiles in Familial HypercholesterolemiaSemantic proximity Read ↗

Phenotype and Response to PAMPs of Human Monocyte-Derived Foam Cells Obtained by Long-Term Culture in the Presence of oxLDLs.Semantic proximity Read ↗

Expression profiling of macrophages from subjects with atherosclerosis to identify novel susceptibility genes.Semantic proximity Read ↗

Pro-inflammatory monocyte-macrophage polarization imbalance in human hypercholesterolemia and atherosclerosis.Semantic proximity Read ↗

Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARγ and LXRα pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.