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Role of Toxoplasma gondii Myosin A in Powering Parasite Gliding and Host Cell Invasion

24 Oct 2002

Abstract excerpt

Obligate intracellular apicomplexan parasites rely on gliding motion powered by their actomyosin system to disperse throughout tissues and to penetrate host cells. Toxoplasma gondii myosin A has been implicated in this process, but direct proof has been lacking. We designed a genetic screen to generate a tetracycline-inducible transactivator system in T. gondii. The MyoA gene was disrupted in the presence of a...

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PMID: 12399593
DOI: 10.1126/science.1074553

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Research trail→

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Role of Toxoplasma gondii Myosin A in Powering Parasite Gliding and Host Cell InvasionPMID 12399593Read ↗

MyosinA is a druggable target in the widespread protozoan parasite Toxoplasma gondii.Semantic proximity Read ↗

The class XIV myosin of <i>Toxoplasma gondii</i> , TgMyoA, is druggable in an animal model of infectionSemantic proximity Read ↗

The toxoplasma Acto-MyoA motor complex is important but not essential for gliding motility and host cell invasion.Semantic proximity Read ↗

<i>Toxoplasma gondii</i> myosins B/CSemantic proximity Read ↗

Reassessing the mechanics of parasite motility and host-cell invasionSemantic proximity Read ↗

How does Toxoplama gondii invade host cells?Semantic proximity Read ↗

‘The glideosome’: a dynamic complex powering gliding motion and host cell invasion by Toxoplasma gondiiSemantic proximity Read ↗

Myosin-dependent cell-cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii.Semantic proximity Read ↗

Screening the Toxoplasma kinome with high-throughput tagging identifies a regulator of invasion and egressSemantic proximity Read ↗

Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite.Semantic proximity Read ↗

Stage-specific depletion of myosin A supports an essential role in motility of malarial ookinetesSemantic proximity Read ↗

Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor.Semantic proximity Read ↗

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