Article
Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor.
Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 2006
Bosch Jürgen, Turley Stewart, Daly Thomas M, Bogh Stephen M, Villasmil Michelle L, Roach Claudia, Zhou Na, Morrisey Joanne M, Vaidya Akhil B, Bergman Lawrence W, Hol Wim G J
Abstract excerpt
The causative agents of malaria have developed a sophisticated machinery for entering multiple cell types in the human and insect hosts. In this machinery, a critical interaction occurs between the unusual myosin motor MyoA and the MyoA-tail Interacting Protein (MTIP). Here we present one crystal structure that shows three different conformations of Plasmodium MTIP, one of these in complex with the MyoA-tail,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.