Article
Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite.
Cell - 22 Mar 1996
Dobrowolski J M, Sibley L D
Abstract excerpt
Toxoplasma gondii is an obligate intracellular parasite that invades a wide range of vertebrate host cells. We demonstrate that invasion is critically dependent on actin filaments in the parasite, but not the host cell. Invasion into cytochalasin D (CD)-resistant host cells was blocked by CD, whi...
Topics
- Actin Cytoskeleton
- Actins
- Animals
- Base Sequence
- Blotting, Western
- Bone Marrow Cells
- Cell Adhesion
- Cell Line
- Cell Movement
- Cytochalasin D
- Cytoskeleton
- Macrophages
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutation
- Toxoplasma