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Article

The Role of Syncytin in Placental Angiogenesis and Fetal Growth

12 Apr 2022

Abstract excerpt

Background: Syncytin, a retroviral envelope protein, is specifically expressed on trophoblast cells and mediates formation of the syncytiotrophoblast through fusogenic activity. Decreased expression of Syncytin was found in fetal growth restriction placentas. Results: By generating an inducible knockout of the syncytin-a gene in mice, we show a specific disruption of placental angiogenesis with abnormal formation...

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Identifiers

PMID: 35493107
DOI: 10.3389/fcell.2022.852561

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