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Article

Characterization of beta-globin haplotypes using blood spots from a population-based cohort of newborns with homozygous HbS.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2000

Crawford Dana C, Caggana Michele, Harris Katharine B, Lorey Fred, Nash Claudia, Pass Kenneth A, Tempelis Corinna, Olney Richard S

Abstract excerpt

PURPOSE: A population-based cohort from three state newborn screening programs was used to describe beta-globin gene cluster variation. METHODS: Blood spots from newborns homozygous for HbS were genotyped for five restriction fragment length polymorphisms (RFLPs) to construct beta-globin haplotypes. Haplotype distributions were compared by race/ethnicity and sex. Expected heterozygosities were calculated and...

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PMID: 12394345
DOI: 10.1097/00125817-200209000-00003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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