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Article

Low Prevalence of the HBB c.20A > T (HbS) Allele in a Turkish Cypriot Cohort: A Molecular Screening Study.

Hemoglobin - 1 Sept 2026

Kandemis Emine, Sulamain Saadatu Sani, Cobanogullari Havva, Fahrioglu Umut, Ergoren Mahmut Cerkez

Abstract excerpt

Sickle cell disease is caused by the HBB c.20A > T (p.Glu6Val; HbS) variant. Although Cyprus has a long-standing hemoglobinopathy prevention program, current population-specific data on HbS among Turkish Cypriots remain limited. Two hundred unrelated Turkish Cypriot adults were included. The HBB c.20A > T variant was genotyped by PCR-RFLP and confirmed by allele-specific real-time PCR. Genotype distribution was...

Read the complete abstract on PubMed

Topics

Humans
Cyprus
Gene Frequency
Turkey
Alleles
Prevalence
Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Hemoglobin, Sickle

Female

Anemia, Sickle Cell

Male

Adult

Heterozygote

beta-Globins

Cohort Studies

Source

Identifiers

PMID: 42547889
DOI: 10.1080/03630269.2026.2709697

Genes

HBB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

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