Article
A lack of SUMO conjugation affects cNLS-dependent nuclear protein import in yeast.
The Journal of biological chemistry - 20 Dec 2002
Stade Katrin, Vogel Frank, Schwienhorst Ingrid, Meusser Birgit, Volkwein Corinna, Nentwig Brigitte, Dohmen R Jürgen, Sommer Thomas
Abstract excerpt
Yeast SUMO (Smt3) and its mammalian ortholog SUMO-1 are ubiquitin-like proteins that can reversibly be conjugated to other proteins. Among the substrates for SUMO modification in vertebrates are RanGAP1 and RanBP2/Nup358, two proteins previously implicated in nucleocytoplasmic transport. Sumoylated RanGAP1 binds to the nuclear pore complex via RanBP2/Nup358, a giant nucleoporin, which was recently reported to act...
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