Article
Gene therapy of apolipoprotein E–deficient mice using a novel macrophage-specific retroviral vector
31 Dec 2002
Abstract excerpt
The use of retroviral gene transfer into hematopoietic stem cells for human gene therapy has been hampered by the absence of retroviral vectors that can generate long-lasting, lineage-specific gene expression. We developed self-inactivating retroviral vectors that incorporate gene-regulatory elements from the macrophage-restricted human CD68 gene. Through the transplantation of transduced murine hematopoietic...
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