Article
Isolation and characterization of genes associated with the anti-tumor activity of glucocorticoids.
Brain research. Molecular brain research - 15 Oct 2002
Vedoy Cleber Giovane, Sogayar Mari Cleide
Abstract excerpt
Treatment of ST1 rat glioma cells with glucocorticoid hormones leads to complete reversion of their transformed phenotype and loss of their tumorigenic potential. In order to study the molecular basis of the anti-tumor activity of these hormones, we isolated glucocorticoid-regulated cDNA sequences associated with ST1 cells' phenotypic reversion, using suppression subtractive hybridization (SSH). DNA sequencing of...
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