Article
Rapid identification of atypical variant of plasma butyrylcholinesterase by PCR.
Clinical chemistry and laboratory medicine - 1 Aug 2002
Ceppa Franck, Gidenne Stephane, Benois Alain, Fontan Eleonore, Burnat Pascal
Abstract excerpt
Human butyrylcholinesterase is the enzyme responsible of mivacurium and succinylcholine metabolism, which may be significantly impaired when mutation Asp70Gly is found in patients. We describe a simple PCR method for the detection of this variant. Thirteen out of sixteen patients tested after prolonged apnea were positive for the presence of this mutation (50.0% homozygotes and 31.3% heterozygotes), suggesting...
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