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Article

Golden mean to longevity: rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinson's disease.

Journal of neuroscience research - 1 Nov 2002

Tanaka Masashi, Fuku Noriyuki, Takeyasu Takeshi, Guo Li-Jun, Hirose Raita, Kurata Miyuki, Borgeld Harm-Jan W, Yamada Yoshiji, Maruyama Wakako, Arai Yasumichi, Hirose Nobuyoshi, Oshida Yoshiharu, Sato Yuzo, Hattori Nobutaka, Mizuno Yoshikuni, Iwata So, Yagi Kunio

Abstract excerpt

To test the hypothesis that centenarians are free from deleterious mitochondrial variations, we analyzed amino acid variations in the cytochrome b molecule of 64 Japanese centenarians. Although the frequencies of some variations, such as N260D and G251S, differed significantly between centenarians and patients with Parkinson's disease, the most striking feature of centenarian cytochrome b was the rareness of...

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PMID: 12391595
DOI: 10.1002/jnr.10444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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