Article
Contribution of an affect-associated gene to human longevity: prevalence of the long-allele genotype of the serotonin transporter-linked gene in Japanese centenarians.
Mechanisms of ageing and development - 1 Nov 2005
Gondo Yasuyuki, Hirose Nobuyoshi, Arai Yasumichi, Yamamura Ken, Shimizu Ken-Ichirou, Takayama Michiyo, Ebihara Yoshinori, Nakazawa Susumu, Inagaki Hiroki, Masui Yukie, Kitagawa Koji
Abstract excerpt
Negative affect such as depression and anxiety has been reported to be associated with morbidity and mortality, and polymorphisms of the serotonin transporter (5HTT) gene may be associated with such affect disorders. Hypothesizing that 5HTT gene polymorphisms could influence human longevity via negative affect; we compared the polymorphic variation of the 5HTT gene between 265 Japanese centenarians and control...
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