Article
Changes in dendritic cell migration and activation during SIV infection suggest a role in initial viral spread and eventual immunosuppression.
Journal of medical primatology - 1 Aug 2002
Barratt-Boyes S M, Zimmer M I, Harshyne L
Abstract excerpt
Dendritic cells (DC) serve an essential function in linking the innate and acquired immune responses to antigen. Peripheral DC acquire antigen and migrate to draining lymph nodes, where they localize to the T cell-rich paracortex and function as potent antigen presenting cells. We examined the effects of human immunodeficiency virus (HIV) infection on DC function in vivo using the rhesus macaque/simian...
Topics
- Animals
- Cell Movement
- Cells, Cultured
- Dendritic Cells
- Disease Models, Animal
- Fluorescein-5-isothiocyanate
- Langerhans Cells
- Lymph Nodes
- Macaca mulatta
- Phenotype
- Simian Acquired Immunodeficiency Syndrome
- Simian Immunodeficiency Virus
- Skin