Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dual functions for connexins: Cx43 regulates growth independently of gap junction formation.

Experimental cell research - 10 Dec 2001

Moorby C, Patel M

Abstract excerpt

Connexins, the family of proteins that form vertebrate gap junctions, have key roles during development and in the adult. Previously, the physiological actions of connexins have been ascribed solely to formation of gap junction channels and thought to be mediated by the transfer of small molecules between neighboring cells. In conflict with this hypothesis here we demonstrate that Cx43 can affect cell growth...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Cell Communication
Share to Cell Compartmentation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Connexin 43

Share to Fluorescent Antibody Technique

Share to Gap Junctions

Share to Indicators and Reagents

Share to Luminescent Proteins

Source

Identifiers

PMID: 11716536
DOI: 10.1006/excr.2001.5357

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dual functions for connexins: Cx43 regulates growth independently of gap junction formation.PMID 11716536Read ↗

A connexin 43 mutant lacking the carboxyl cytoplasmic domain inhibits both growth and motility of mouse 3T3 fibroblasts.Semantic proximity Read ↗

Expression of a Cx43 deletion mutant in 3T3 A31 fibroblasts prevents PDGF-induced inhibition of cell communication and suppresses cell growth.Semantic proximity Read ↗

Modulation of astrocyte P2Y1 receptors by the carboxyl terminal domain of the gap junction protein Cx43.Semantic proximity Read ↗

Connexin genes and cell growth control.Semantic proximity Read ↗

Regulation of connexin-43-mediated growth inhibition by a phosphorylatable amino-acid is independent of gap junction-forming ability.Semantic proximity Read ↗

Immortalized connexin43 knockout cell lines display a subset of biological properties associated with the transformed phenotype.Semantic proximity Read ↗

Deletion of a single allele of Cx43 is associated with a reduction in the gap junctional intercellular communication and increased cell proliferation of mouse lung pneumocytes type II.Semantic proximity Read ↗

Role of connexin (gap junction) genes in cell growth control: approach with site-directed mutagenesis and dominant-negative effects.Semantic proximity Read ↗

Connexin43 inhibits the oncogenic activity of c-Src in C6 glioma cells.Semantic proximity Read ↗

A carboxyl terminal domain of connexin43 is critical for gap junction plaque formation but not for homo- or hetero-oligomerization.Semantic proximity Read ↗

Mechanism of v-Src- and mitogen-activated protein kinase-induced reduction of gap junction communication.Semantic proximity Read ↗

Dominant-negative abrogation of connexin-mediated cell growth control by mutant connexin genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.