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Article

PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1.

The Journal of clinical investigation - 1 Dec 2009

Wang Guey-Shin, Kuyumcu-Martinez Muge N, Sarma Satyam, Mathur Nitin, Wehrens Xander H T, Cooper Thomas A

Abstract excerpt

Cardiac complications are a common cause of death in individuals with the inherited multisystemic disease myotonic dystrophy type 1 (DM1). A characteristic molecular feature of DM1 is misregulated alternative splicing due to disrupted functioning of the splicing regulators muscleblind-like 1 (MBN...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19907076
DOI: 10.1172/JCI37976
PMCID: PMC2786786

Genes

MBNL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19907076-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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