Article

Cladribine induces apoptosis in human leukaemia cells by caspase-dependent and -independent pathways acting on mitochondria

2001-10-25

Abstract excerpt

We have studied the role of caspases and mitochondria in apoptosis induced by 2-chloro-2′-deoxyadenosine (cladribine) in several human leukaemic cell lines. Cladribine treatment induced mitochondrial transmembrane potential (ΔΨm) loss, phosphatidylserine exposure, caspase activation and development of typical apoptotic morphology in JM1 (pre-B), Jurkat (T) and U937 (promonocytic) cells. Western-blot analysis of ce...

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Literature Corpus work: c912b730-8ecb-5eda-a6a7-ca93781a4c0d
DOI: 10.1042/bj3590537

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